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De novo mutational signatures extraction was executed with SparseSignatures20. This Resource adopts LASSO regularisation to improve the healthy, controlled by a regularisation parameter lambda (λ). It implements a plan depending on bi-cross-validation to estimate the ideal values for each the regularisation parameter λ and the quantity of signatures.
The y-axis would be the reads counts from E.coli. The crimson/gray colour with the bars denotes the existence/absence of clb genes given that the clb genes represent pks genomic island and encoding colibactin.
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